Particularly, the relationship anywhere between overall protein intake and you can solution uric acid profile remains not sure

Individuals are not ate items have long come suspected of impacting new gel uric acid peak, but partners analysis are around for help or refuse it impact. Our objective would be to assess the relationships ranging from dieting points and you can gel uric acid levels when you look at the a nationally associate shot of males and women in the usa.


Having fun with research from fourteen,809 professionals (six,932 guys and you will eight,877 females) years two decades and you can older on 3rd Federal Health and Nourishment Test Survey (into years 1988–1994), we examined the partnership amongst the intake out-of purine-steeped meals, protein, and you may dairy food and you may serum amounts of uric acid. Diet is actually assessed that have a dinner-volume questionnaire. I put multivariate linear regression to adjust to own decades, intercourse, full energy consumption, body mass index, accessibility diuretics,, allopurinol, and uricosuric agents, self-advertised hypertension and you can gout, gel creatinine peak, and you may intake out-of alcohol.


The serum uric acid level increased with increasing total meat or seafood intake and decreased with increasing dairy intake. After adjusting for age, the differences in uric acid levels between the extreme quintiles of intake were 0.48 mg/dl for total meat (95% confidence interval [95% CI] 0.34, 0.61; P < 0.001 for trend), 0.16 mg/dl for seafood (95% CI 0.06, 0.27; P = 0.005 for trend), and –0.21 mg/dl for total dairy intake (95% CI –0.37, –0.04; P = 0.02 for trend). After adjusting for other covariates, the differences between the extreme quintiles were attenuated but remained significant (P < 0.05 for all comparisons). The total protein intake was not associated with the serum uric acid level in multivariate analyses (P = 0.74 for trend). Those who consumed milk 1 or more times per day had a lower serum uric acid level than did those who did not drink milk (multivariate difference –0.25 [95% CI –0.40, –0.09]; P < 0.001 for trend). Similarly, those who consumed yogurt at least once every other day had a lower serum uric acid level than did those who did not consume yogurt (multivariate difference –0.26 [95% CI –0.41, –0.12]; P < 0.001 for trend).


Such conclusions from a nationally associate test off grownups in the You recommend that high degrees of animal meat and you will seafood consumption are with the highest serum degrees of uric acid however, that overall necessary protein consumption isn’t. Whole milk usage is inversely associated with the serum the crystals top.

Hyperuricemia is definitely the precursor from gout, which is the most commonly known sort of inflammatory osteoarthritis during the adult males ( step one ). Certain commonly ate dinners have long already been suspected out of affecting the latest solution uric acid account, but couples investigation appear. Such as for instance, customers having hyperuricemia or gout are typically advised to get rid of habitual intake away from purine-steeped foods such as for instance animal meat and seafood ( 2 , 3 ), but investigation concerning the genuine matchmaking ranging from these foods and you may gel quantities of uric acid is scarce. Past metabolic studies used fake loading off refined purine ( 4-7 ) however, didn’t elucidate the connection in order to genuine snacks. In the event highest-healthy protein dieting usually contain large volumes from purines, the brand new uricosuric feeling in the such diets get, actually, also down solution uric acid levels ( step 3 , 8 , 9 ). Furthermore, limited research recommend that there may be an enthusiastic inverse relationships ranging from whole milk device practices and you will solution uric-acid accounts ( 10 , 11 ). When you look at the a current large prospective study of experience gout certainly one of guys, we unearthed that higher meat and you may fish intake individually increased the fresh likelihood of experience gout, when you’re large whole milk consumption is protective resistant to the chance ( twelve ). Further, large proteins intake don’t increase the risk ( twelve ). The relationship between these weightloss affairs additionally the level of gel uric-acid, not, was not looked at in this cohort.